Anti-amnesic effect of prolyl endopeptidase inhibitors in mice.
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چکیده
منابع مشابه
Structure activity relationship of inhibitors specific for prolyl endopeptidase.
Structural requirements of N-blocked L-proline derivatives as specific inhibitors for prolyl endopeptidase were investigated using a series of substrate analogs. Replacement of L-proline by its D-isomer remarkably reduced the inhibition. Introduction of a sulfur atom in proline and/or in the penultimate pyrrolidine rings significantly increased the inhibition, but the introduction of oxygen rat...
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anti-umnesic efTect on Alzheimer's rats.fi) In PCI2・ h cells staurosporine blocked NGF-induced neuriLe outgrowth at low doses. but at hLgher doses PCI2h cclls responded te staurospovine blr' rupid generation of neurites.4) The meehanisms of neurite outgrewth prompted by staurosporine might be difTl:Fent from that ofNGF. dB-cAMP, or infection witli a retrovirus carr},ing the v-src oncogene.4] It...
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Prolyl endopeptidase (PEP, EC 3.4.21.26) has been proposed to play a role in degradation of proline-containing neuropeptides involved in the processes of learning and memory, e.g., vasopressin, substance P, and thyrotropin-releasing hormone (TRH). In the course of our search for bioactive constituents in medicinal plants, we studied the PEP inhibitory constituents of the roots of Lindera strych...
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Prolyl peptidases cleave proteins at proline residues and are of importance for cancer, neurological function, and type II diabetes. Prolyl endopeptidase (PEP) cleaves neuropeptides and is a drug target for neuropsychiatric diseases such as post-traumatic stress disorder, depression, and schizophrenia. Previous structural analyses showing little differences between native and substrate-bound st...
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An Induced-Fit Mechanism for Prolyl Endopeptidase Min Li 2 , Changqing Chen 3 , David R Davies 2 , and Thang K Chiu 1,2 . From the Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, 2 Lab of Molecular Biology, National Institute of Diabetes Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Mary...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 1987
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.89.323